5c–d). CX-5461-mediated S33 phosphorylation of RPA was independent from the mobile cycle stage and was not restricted to the nucleoli in HR-deficient cells. Therefore, the development of ssDNA constructions in CX-5461 taken care of cells can lead to replication fork stalling and ATR activation with HRD exacerbating CX-5461-mediated replication tension https://aristotlek655wht8.topbloghub.com/profile